Targeting tumor hypoxia with 2-nitroimidazole-indocyanine green dye conjugates
نویسندگان
چکیده
منابع مشابه
Targeting tumor hypoxia: a third generation 2-nitroimidazole-indocyanine dye-conjugate with improved fluorescent yield.
Tumor hypoxia is associated with the rapid proliferation and growth of malignant tumors, and the ability to detect tumor hypoxia is important for predicting tumor response to anti-cancer treatments. We have developed a class of dye-conjugates that are related to indocyanine green (ICG, ) to target tumor hypoxia, based on in vivo infrared fluorescence imaging using nitroimidazole moieties linked...
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OBJECTIVE To determine the elimination kinetics of indocyanine green (ICG) after intraocular operations using ICG staining. METHODS Intraocular fluorescence of ICG was determined using the ICG angiographic mode of a scanning laser ophthalmoscope (in vivo) and fluorescence microscopy (in vitro) after circular curvilinear capsulorhexis with ICG staining during cataract surgery and internal limi...
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Hypoxia has been known be an important physiological parameter for tumor growth and has been reported to be the cause for poor response to chemotherapy. Mechanistically, tumor hypoxia results from an imbalance between oxygen delivery and oxygen consumption. The identification and quantification of tumor hypoxia may predict the out come and may identify patients who might benefit from concomitan...
متن کاملDoes precipitation reduce tissue staining by indocyanine green dye solutions?
PURPOSE Indocyanine green (ICG) dye precipitates when mixed with certain ophthalmic irrigation solutions. The purpose of this study is to investigate whether this precipitation reduces ICG staining of the anterior lens capsule. METHODS ICG was diluted with each of the following solutions: BSS Plus, physiological saline, or Opeguard Neo. The products were then examined for green precipitate by...
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INTRODUCTION Sentinel lymph node (SLN) biopsy is a vital component of staging and management of multiple cancers. The current gold standard utilizes technetium 99 (tech99) and a blue dye to detect regional nodes. While the success rate is typically over 90%, these two methods can be inconclusive or inconvenient for both patient and surgeon. We evaluated a new technique using laser-assisted ICG ...
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ژورنال
عنوان ژورنال: Journal of Biomedical Optics
سال: 2013
ISSN: 1083-3668
DOI: 10.1117/1.jbo.18.6.066009